Joyal Lab

Insulin therapy in acute decompensation of holocarboxylase synthetase deficiency with hyperglycemia and ketoacidosis.

Demaret T, Joyal JS, Karalis A, Parente F, Delrue MA, Mitchell GA.Mol Genet Metab Rep. 2024 Mar 21;39:101073. doi: 10.1016/j.ymgmr.2024.101073. eCollection 2024 Jun.PMID: 38550975

 

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P.Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6.PMID: 38321220

 

Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue.

Song AT, Sindeaux RHM, Li Y, Affia H, Agnihotri T, Leclerc S, van Vliet PP, Colas M, Guimond JV, Patey N, Feulner L, Joyal JS, Haddad E, Barreiro L, Andelfinger G.Cell Rep. 2024 Jan 23;43(1):113616. doi: 10.1016/j.celrep.2023.113616. Epub 2023 Dec 26.PMID: 38150367

 

Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior.

Mohammad Nezhady MA, Cagnone G, Joyal JS, Chemtob S.Cell Commun Signal. 2023 Nov 9;21(1):196. doi: 10.1186/s12964-023-01188-z.PMID: 37940970

 

NOX2 deficiency enhances priming and activation of the NLRP3 inflammasome.

Monjarret B, Shour S, Benyoucef A, Heckel E, Marchitto L, Leiding JW, Cros G, Fernandez I, Joyal JS, Touzot F.J Allergy Clin Immunol. 2023 Oct 5:S0091-6749(23)01242-3. doi: 10.1016/j.jaci.2023.09.030. Online ahead of print.PMID: 37805023

 

Peroxisome disruption alters lipid metabolism and potentiates antitumor response with MAPK-targeted therapy in melanoma.

Huang F, Cai F, Dahabieh MS, Gunawardena K, Talebi A, Dehairs J, El-Turk F, Park JY, Li M, Goncalves C, Gagnon N, Su J, LaPierre JH, Gaub P, Joyal JS, Mitchell JJ, Swinnen JV, Miller WH Jr, Del Rincón SV.J Clin Invest. 2023 Oct 16;133(20):e166644. doi: 10.1172/JCI166644.PMID: 37616051

 

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.

Da Silva A, Dort J, Orfi Z, Pan X, Huang S, Kho I, Heckel E, Muscarnera G, van Vliet PP, Sturiale L, Messina A, Romeo DA, van Karnebeek CDM, Wen XY, Hinek A, Molina T, Andelfinger G, Ellezam B, Yamanaka Y, Olivos HJ, Morales CR, Joyal JS, Lefeber DJ, Garozzo D, Dumont NA, Pshezhetsky AV.Sci Adv. 2023 Jun 30;9(26):eade6308. doi: 10.1126/sciadv.ade6308. Epub 2023 Jun 30.PMID: 37390204

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Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity.

Dominici C, Villarreal OD, Dort J, Heckel E, Wang YC, Ragoussis I, Joyal JS, Dumont N, Richard S.Elife. 2023 Jun 7;12:RP84570. doi: 10.7554/eLife.84570.PMID: 37285284

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Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.

Hata M, Hata M, Andriessen EM, Juneau R, Pilon F, Crespo-Garcia S, Diaz-Marin R, Guber V, Binet F, Fournier F, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM, Sapieha P.J Clin Invest. 2023 Feb 15;133(4):e159757. doi: 10.1172/JCI159757.PMID: 36787231

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Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.

Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P.Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894. Epub 2023 Jan 5.PMID: 36603072

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Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin-bound iron.

Charlebois E, Fillebeen C, Presley J, Cagnone G, Lisi V, Lavallée VP, Joyal JS, Pantopoulos K.Blood. 2023 Jan 19;141(3):271-284. doi: 10.1182/blood.2022016987.PMID: 36351237 

 

The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions.

Sanchez M, Hamel D, Bajon E, Duhamel F, Bhosle VK, Zhu T, Rivera JC, Dabouz R, Nadeau-Vallée M, Sitaras N, Tremblay DÉ, Omri S, Habelrih T, Rouget R, Hou X, Gobeil F, Joyal JS, Sapieha P, Mitchell G, Ribeiro-Da-Silva A, Mohammad Nezhady MA, Chemtob S.Cells. 2022 Jul 13;11(14):2185. doi: 10.3390/cells11142185.PMID: 35883628

 

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.

Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wünnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JS. JCI Insight. 2022 Mar 22;7(6):e154174. doi: 10.1172/jci.insight.154174.PMID: 35167498

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Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes.

Raggi C, M'Callum MA, Pham QT, Gaub P, Selleri S, Baratang NV, Mangahas CL, Cagnone G, Reversade B, Joyal JS, Paganelli M. Stem Cell Reports. 2022 Mar 8;17(3):584-598. doi: 10.1016/j.stemcr.2022.01.003. Epub 2022 Feb 3.PMID: 35120625

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eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.

Smith TL, Oubaha M, Cagnone G, Boscher C, Kim JS, El Bakkouri Y, Zhang Y, Chidiac R, Corriveau J, Delisle C, Andelfinger GU, Sapieha P, Joyal JS, Gratton JP.Cell Mol Life Sci. 2021 Dec 31;79(1):37. doi: 10.1007/s00018-021-04042-y.PMID: 34971428

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Cardiac Left Ventricle Mitochondrial Dysfunction After Neonatal Exposure to Hyperoxia: Relevance for Cardiomyopathy After Preterm Birth.

Ravizzoni Dartora D, Flahault A, Pontes CNR, He Y, Deprez A, Cloutier A, Cagnone G, Gaub P, Altit G, Bigras JL, Joyal JS, Mai Luu T, Burelle Y, Nuyt AM.Hypertension. 2021 Dec 28:HYPERTENSIONAHA12117979. doi: 10.1161/HYPERTENSIONAHA.121.17979. Online ahead of print.PMID: 34961326

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Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.

Brais-Brunet S, Heckel É, Kanniyappan U, Chemtob S, Boudoux C, Joyal JS, Dehaes M.Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):20. doi: 10.1167/iovs.62.13.20.PMID: 34698774 

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Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies.

Othman R, Cagnone G, Joyal JS, Vaucher E, Couture R.Cells. 2021 Jul 28;10(8):1913. doi: 10.3390/cells10081913.PMID: 34440682 

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation.

Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A.

Dev Cell. 2021 Jul 12:S1534-5807(21)00528-1. doi: 10.1016/j.devcel.2021.06.021. Online ahead of print.

PMID: 34273276

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Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration.

Fu Z, Qiu C, Cagnone G, Tomita Y, Huang S, Cakir B, Kotoda Y, Allen W, Bull E, Akula JD, Joyal JS, Hellström A, Talukdar S, Smith LEH.

iScience. 2021 Mar 29;24(4):102376. doi: 10.1016/j.isci.2021.102376. eCollection 2021 Apr 23.

PMID: 33937726

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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O'Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P.

Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5.

PMID: 33548171

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An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration.

Dabouz R, Cheng CWH, Abram P, Omri S, Cagnone G, Sawmy KV, Joyal JS, Desjarlais M, Olson D, Weil AG, Lubell W, Rivera JC, Chemtob S.J Neuroinflammation. 2020 Nov 27;17(1):359. doi: 10.1186/s12974-020-02032-8.

PMID: 33246504

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Vitreous metabolomics profiling of proliferative diabetic retinopathy.

Tomita Y, Cagnone G, Fu Z, Cakir B, Kotoda Y, Asakage M, Wakabayashi Y, Hellström A, Joyal JS, Talukdar S, Smith LEH, Usui Y.

Diabetologia. 2021 Jan;64(1):70-82. doi: 10.1007/s00125-020-05309-y. Epub 2020 Oct 25.

PMID: 33099660

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Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.

Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F,       Joyal JS*, Mallette FA*, Sapieha P*. (*Co-corresponding authors)

Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356.

PMID: 32820093

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OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation.

Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A.

Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z.

PMID: 32807793

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Fulminant Necrotizing Enterocolitis and Multiple Organ Dysfunction in a Toddler with Mitochondrial DNA Depletion Syndrome-13.

Nardi N, Proulx F, Brunel-Guiton C, Oligny LL, Piché N, Mitchell GA, Joyal JS.

J Pediatr Intensive Care. 2020 Mar;9(1):54-59. doi: 10.1055/s-0039-1697620. Epub 2019 Oct 10.

PMID: 31984159 

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Should We Care About Pediatric Multiple Organ Dysfunction Syndrome?

Proulx F, Joyal JS, Lacroix J.

Pediatr Crit Care Med. 2019 Oct;20(10):987-988. doi: 10.1097/PCC.0000000000002066.

PMID: 31580273 

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Immunometabolic modulation of retinal inflammation by CD36 ligand.

Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Pundir S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H.

Sci Rep. 2019 Sep 9;9(1):12903. doi: 10.1038/s41598-019-49472-8.

PMID: 31501473

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Dyslipidemia in retinal metabolic disorders.

Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellström A, Joyal JS, Smith LE.

EMBO Mol Med. 2019 Oct;11(10):e10473. doi: 10.15252/emmm.201910473. Epub 2019 Sep 5.

PMID: 31486227

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Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Madaan A, Chaudhari P, Nadeau-Vallée M, Hamel D, Zhu T, Mitchell G, Samuels M, Pundir S, Dabouz R, Howe Cheng CW, Mohammad Nezhady MA, Joyal JS, Rivera JC, Chemtob S.

Am J Pathol. 2019 Sep;189(9):1878-1896. doi: 10.1016/j.ajpath.2019.05.016. Epub 2019 Jun 18.

PMID: 31220454

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NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.

PMID: 30787185 

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Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

Beaudry-Richard A, Nadeau-Vallée M, Prairie É, Maurice N, Heckel É, Nezhady M, Pundir S, Madaan A, Boudreault A, Hou X, Quiniou C, Sierra EM, Beaulac A, Lodygensky G, Robertson SA, Keelan J, Adams Waldorf KM, Olson DM, Rivera JC, Lubell WD, Joyal JS, Bouchard JF, Chemtob S.

Sci Rep. 2018 Aug 8;8(1):11875. doi: 10.1038/s41598-018-30087-4.

PMID: 30089839

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Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism.

Joyal JS*, Gantner ML, Smith LEH*. (*Co-corresponding authors)

Prog Retin Eye Res. 2018 May;64:131-156. doi: 10.1016/j.preteyeres.2017.11.002. Epub 2017 Nov 22. Review. No abstract available.

PMID: 29175509

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Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Joyal JS*, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, et al. (*Co-corresponding authors)

Nat Med. 2016 Apr;22(4):439-45. doi: 10.1038/nm.4059. Epub 2016 Mar 14.

PMID: 26974308

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Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Joyal JS*, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, et al. (*Co-corresponding authors)

Nat Med. 2014 Oct;20(10):1165-73. doi: 10.1038/nm.3669. Epub 2014 Sep 14.

PMID: 25216639

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SOCS3 is an endogenous inhibitor of pathologic angiogenesis.

Stahl A* , Joyal JS*, Chen J, Sapieha P, Juan A M, et al. (co-first author)

Blood, 2012 Oct 4;120(14):2925-9.

PMID: 22791286

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Ischemic neurons prevent vascular regeneration of neural tissue by secreting Semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, et al.

Blood, 2011 Jun 2;117(22):6024-35. 

PMID: 21355092

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Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.

Sapieha P, Joyal JS, Rivera JC,  Kermorvant-Duchemin E, Sennlaub F, et al.

J Clin Invest. 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.

PMID: 20811158

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The succinate receptor GPR91 present on neurons, exerts a major role in retinal angiogenesis.

Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, et al.

Nature Medicine 2008 Oct;14(10):1067-76.

PMID: 18836459